Get Your Short-Term Memory Back With Cognitex
By Joe Hammond
A new article published in the December 2019 issue of Life Extension magazine, about the ingredients of our new Cognitex Elite, is an eye opening account on getting short-term memory restored. I will include the full article at the end of my personal story about Cognitex.
Life Extension started 40 years ago and Cognitex has been one of its leading supplements for brain health for many years. The scientists and doctors who are part of the team at Life Extension are constantly doing research to improve our supplements, and develop new ones.
This year they came up with a new supplement, Cognitex Elite and they stated it is the best brain supplement they have ever developed in the last 40 years. I wanted to test this bold statement for myself because at 77 I was having a battle with my short-term memory and that is exactly what the new Cognitex Elite is targeting.
What was happening to my short-term memory
About a year ago I started having a hard time remembering if I took a specific prescription eye drop at its specified time. I had to find a way to keep track.I had to layout a checkerboard configuration with my eye drop bottles. I would move them to the next time square after I used each one and it worked. If I didn’t take the drops as proscribed I could go blind so I knew I had to make it work and it did.
Other things started to happen. I would walk into another room to get something or do something and I would forget why I went there. I usually remembered my purpose after returning to the first room.
An idea would flash through my mind and it would be difficult to hold it in my mind for a period of time, if I was driving or engaged in something where I couldn’t write it down.
All this didn’t happen all the time, my friends and family didn’t notice anything but I was getting concerned. I called some of my friends who were also in their 70’s and asked them if they were having the same problems. They all said yes, but not to worry, I was just experiencing a senior moment.
I didn’t like their answer, I knew that our problems were happening because the communication between brain cells was not always working properly, so I started my own research on the subject.
I found the problem. Our neurotransmitters were not working as they should, which happens as you grow older. There are a number of neurotransmitters and a research paper from the Queensland Brain Institute named the neurotransmitter I was looking for, acetylcholine.
Here is an illustration and part of the incredible information I read in a research paper from the Queensland Brain Institute at the University of Queensland Australia.
The first neurotransmitter to be discovered was a small molecule called acetylcholine. It plays a major role in the peripheral nervous system, where it is released by motor neurons and neurons of the autonomic nervous system. It also plays an important role in the central nervous system in maintaining cognitive function.
So now I know it is a neurotransmitter problem and the one involved in cognitive function is called acetylcholine.
I found an article in the January 2019 issue of Life Extension Magazine that looked promising.
Here is an excerpt of what I found in the article. Read it in detail, as it looks like the answer.
Sage Extracts Protect the Brain
Age-related mental decline, including mild cognitive impairment, is a normal part of brain aging.
Many factors lead to dwindling cognitive functions.
Clinical data on a novel sage extract indicates additional protective effects.
Role of Acetylcholine on Short-Term Memory
Neurotransmitters are compounds brain cells use to communicate with one another.
Acetylcholine is a neurotransmitter critical for memory, attention, and reasoning. With aging and neurodegenerative disorders, acetylcholine levels can be depleted.4
This decrease in acetylcholine is responsible for many age-related deficits, including poor memory and the inability to pay attention to tasks.5
This special type of Sage extract plus 6 other powerful brain supplements were in the new Cognitex. I ordered the Cognitex Elite with Pregnenolone and started taking it. The research papers stated that people taking the supplement improved their short-term memory 60% the same day. I didn’t feel any different that first day but kept taking the two pills first thing in the morning as directed on the bottle. I didn’t think about it, I just took them and hoped for the best. Two weeks later I was zipping around all day, getting a lot done and I realized I knew where everything was, remembered everything I was forgetting before, always knowing where I left my glasses, my keys and everything else. Maybe I was just having a good day.
Here I am 5 months later on November 18, 2019 and every day during the last 5 months my short-term memory has been better than any time in my life. It is unbelievable, I remember where I put everything, always know why I have gone into another room, can concentrate on anything, I even remember things from the past, 20, 30, 50 years that I haven’t thought about for a long time.
Continue reading if you want to read the latest article about Cognitex. The article doesn’t mention Cognitex it just explains each function of all 7 ingredients in Cognitex. It is in the Life Extension Magazine written as an article not as an ad.
Life Extension Magazine®
Issue: December 2019
Protect Brain Function with Sage Extract
A sage extract has been clinically shown to increase memory performance in older adults by 60%. Measures of attention improved 2.5-fold within hours of ingestion.
By Michael Downey
As we age, our cognitive abilities decline.
But it doesn’t have to be this way.
Scientists have identified specific nutrients that protect the aging brain.1-10
One of these is a sage extract that has demonstrated remarkable cognitive-enhancing activities.11
In clinical studies, this sage extract increased memory performance in older adults by nearly 60%.
A measure of attention improved by about 2.5-fold—within hours of ingestion.12
In addition to these human benefits, this sage extract has been shown to increase lifespan by 12% in an animal model of aging.11
Together with other nutrients, this sage extract can help our brains function in a more youthful manner.
Preserving Brain Power
Minor deterioration in brain function is known as mild cognitive impairment. It affects memory, attention, and other mental processes.
More severe loss is considered dementia, which includes Alzheimer’s disease.
Alzheimer’s and other forms of dementia are characterized in part by lower levels of the neurotransmitter acetylcholine.
Losing memory and brainpower is not “a part of life” that everyone must endure.
Research has documented that certain nutrients help maximize brain function. The herb sage stands out for its ability to protect neurons and enhance cognitive function.13-18
A team of scientists has identified a new sage extract that provides powerful brain-protective effects not found in other sage preparations.11,12,19
What You Need to Know
SAGE BOOSTS BRAIN POWER
- Scientists have identified a unique sage extract that increases memory performance in older adults by nearly 60% and improves a measure of attention by 2.5-fold—within hours of ingestion.
- This new extract has neuroprotective capabilities not seen in other sage preparations, and it shows the ability to extend lifespan in animal models of aging by 12%.
- This sage extract can help support brain health, especially if taken with other supplements with proven brain benefits.
Cognitive Benefits of Sage
Sage is rich in polyphenols that have demonstrated clinical benefits and fascinating preclinical findings.
But the most compelling benefit of sage may be its capacity for cognitive protection.
In a series of clinical trials, scientists found that younger individuals who took sage extract benefited within hours from improved mood, reduced anxiety, enhanced long-term memory, and reduced mental fatigue.13-16
Researchers also documented cognitive benefits in older people with dementia.17,18
In a randomized clinical trial on patients with mild-to-moderate Alzheimer’s, the cognitive scores of a placebo group deteriorated by about 22% over four months. But the scores of the group that supplemented with sage extract improved by about 26%.18
That’s a remarkable result. But even stronger brain protection is available from a new sage extract.
An Improved Form of Sage
A group of European scientists has identified a specific form of sage with benefits that go beyond traditional sage extracts.
This extract has a unique chemical fingerprint,19 one distinctively suited to support brain function.
In fact, this newer sage extract has shown, in preclinical studies, superior effects to other sage sources and to cognitive drugs.11,20
Scientists enlisted adults over age 64 for a clinical study of its effects on cognition.12 Brain function tests were conducted both before and after participants were given either the sage extract or a placebo.
Here are the remarkable findings:12
- Memory performance in those receiving this new sage extract was boosted, compared to placebo, by roughly 60%.
- A measure of attention in sage-supplemented participants was enhanced, compared to placebo, by about 2.5-fold.
These improvements occurred within hours of taking this new sage extract.12
How It Works
Life Extension® has collaborated with researchers at a group called Sibelius to determine how this particular extract enhances memory and attention.
Traditional sage helps protect the aging brain and supports cognition by:
- Reversing decreases of the neurotransmitter acetylcholine,12,15-17,21,22 which is critical for attention, memory, and reasoning,23-25
- Boosting levels of neurotrophins,22 proteins that encourage creation of new brain cells and repair of damaged brain cells,26-27 and
- Reducing inflammation22 which is associated with cognitive deficits.28
The new sage extract does all this. But scientists have identified several additional ways that this extract, with its different chemical makeup, may deliver cognitive enhancements.
Improved Lipid Metabolism and Insulin Signaling
In a compelling preclinical analytic study, this unique sage extract was found to increase expression of genes related to lipid metabolism and insulin signaling—which are both tied to enhanced longevity.21 Blood tests in aging adults often reveal dangerous increases in glucose, cholesterol, and triglycerides.
In a model of aging using roundworms, this extract resulted in a 12% lifespan increase. Other sage sources did not extend life.11
Stronger Neurotransmitter Signaling
In addition to the increased acetylcholine levels induced by other sage sources, this extract boosts the activity of other neurotransmitters such as GABA (gamma-aminobutyric acid) and glutamate.21
This helps explain the profound cognitive benefits observed in human studies.
Increased Blood Flow to the Brain
As we age, our brain suffers blood flow reductions due to vascular stiffening and damage to delicate capillary beds.
This new sage extract has vasodilation properties, which means it can open vessels that supply vital blood and oxygen to the brain.21
The age-related reduction of blood flow is a precursor to memory loss and dementia.29-33
Other Nutrients for Brain Health
Sage is just one of several nutrients known to protect and enhance brain health. By taking it with others that complement its activity, it can maximize cognitive benefits.
Phosphatidylserine is an essential phospholipid component of nerve cell membranes and the myelin sheath that covers and protects nerve cells, including brain cells. The myelin sheath supports the conduction of nerve impulses throughout the nervous system.1,34,35
Taking phosphatidylserine preserves cognitive function and may reduce the structural deterioration in the nervous system that occurs with age. In studies, people who took it scored higher on short-term memory and concentration tests.1
Blueberries are packed with anthocyanins, powerful compounds present in a variety of plants including fruits and vegetables. Anthocyanins exert a broad range of health-promoting effects, including defense against oxidative stress, as well as modulation of gene expression and cell-signaling pathways.36
Recent human trials have demonstrated that blueberries improve memory and other cognitive performance in older subjects, and boost mood and cognition in children and young adults.3-5,37,38
Vinpocetine, a compound derived from the periwinkle plant, has been reported to have benefits for cognition and degenerative disorders of the brain such as Alzheimer’s and Parkinson’s disease. Vinpocetine helps to dilate (widen) blood vessels to the brain, improving blood flow and stimulating brain metabolism.6
Studies in animals and humans have shown that pregnenolone, a hormone produced by the adrenal gland, appears to be a neuroprotectant, defending the brain from various forms of injury.39,40
It has also been found to have positive effects on mood, memory, and other aspects of cognition.7
Ashwagandha is an Indian herb, also referred to as “Indian ginseng.” It has been used in traditional Indian medicine as a nerve tonic for thousands of years.
In modern research, ashwagandha has demonstrated neuroprotective effects and improvements in mood and cognition.8,9 One study in patients suffering from mild cognitive impairment found that ashwagandha supplementation led to improvements in memory, attention, and decision making.8
Scientists have identified a unique sage extract that has a biological makeup and neuroprotective effects never seen before.
Clinical evidence demonstrates that, within just hours of ingestion, this extract increases memory performance in older adults and improves measures of attention.
This new extract was also shown to increase lifespan by 12% in an animal model of aging.
Sage offers critical protection against cognitive decline.
Taken with other neuroprotective nutrients, such as phosphatidylserine, blueberry, vinpocetine, pregnenolone, and ashwagandha, it can be part of a multivitamin for the brain.