Results from a meta-analysis published in Clinical Research in Hepatology and Gastroenterology found an association between severe vitamin D deficiency in patients with cirrhosis of the liver and a significantly greater risk of dying during follow-up periods ranging from 147 to 419 days.*
For the meta-analysis, researchers selected eight studies that included a total of 1,339 subjects with liver cirrhosis. Study reports included subjects’ serum 25-hydroxyvitamin D levels and provided data concerning mortality from all causes. While vitamin D levels of less than 20 ng/mL were categorized as deficient, severe deficiency was defined as a level of less than 10 ng/mL. Being severely deficient in vitamin D was associated with a 79% greater mortality risk during follow-up, in comparison with having higher levels of the vitamin.
Editor’s Note: Vitamin D deficiency of less than 6 ng/mL was associated with an even greater risk of dying during follow-up. Severe deficiency was also associated with cirrhosis severity.
*Clin Res Hepatol Gastroenterol. 2019 Mar 29.
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